![]() ![]() P-TEFb stimulates productive elongation through releasing promoter-proximal paused RNAPII into gene bodies. Together with a cyclin T subunit, CDK9 forms the positive transcription elongation factor b (P-TEFb) that is required for efficient transcription of most RNAPII-transcribed genes. CDK9 is the most extensively studied transcriptional CDK. Contrary to cycling CDKs whose activity varies during the cell cycle, due to regulated cyclin degradation (this is the case for CDK1, 2, 3, 4 and 6), transcriptional CDKs keep generally constant levels of expression and activity. Both ‘cycling CDKs’ and ‘transcriptional CDKs’ associate with a cyclin regulatory subunit that is essential for enzymatic activity. ![]() Cyclin dependent kinases (CDK) are serine/threonine kinases that are involved in either cell division (by promoting progression through the cell cycle), transcription by RNAPII, or both. ![]()
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